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We demonstrate robust, concentration-dependent formation of [4Fe4S], [2Fe2S] and mononuclear iron clusters using UV-Vis spectroscopy, 57 Fe-Mössbauer spectroscopy and 1 H-NMR
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Of note, in vitro experiments demonstrated that the increased pressure can trigger cancer cells to create autocrine gradients of CCR7 ligands and secrete them into the extracellular matrix (ECM), subsequently driving cancer LN metastasis via CCR7-dependent chemotaxis in the direction of flow toward functional lymphatic vessels (121)
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