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Circulating Fe 3+ enters cells with the assistance of transferrin and subsequently converts to Fe 2+ ( 2+ can catalyze the generation of metabolically toxic reactive oxygen species and phospholipid peroxide through the Fenton reaction, leading to cell damage or death (Figure 4)
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[DOI] [PMC free article] [PubMed] [Google Scholar] 249.Tam CS, Lecoultre V, Ravussin E
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