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Brassington et al 93 demonstrated that chronic cigarette smoke exposure promotes oxidative damage and perturbs cell function, which leads to endothelial-type NO synthase downregulation in Sprague–Dawley rats
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Concurrently, all participants performed aerobic exercise, including running and cycling, with 40- to 60-min training sessions 5 to 6 times each week while taking the NMN orally [145]
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