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31 Other notable loci include RAD50/IL13 on 5q31 (involved in IL-13 regulation), 32 HLA-DQ and other MHC region genes (especially linked to childhood onset and atopy), ADAM33 (implicated in airway remodeling), 33 and CHRD (chr11, possibly related to TGF-β signaling)
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This modification allows IGF-1 LR3 to remain free-floating in the bloodstream and exert more direct anabolic effects (Jones & Clemmons, Endocrine Reviews )
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