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In addition, the oxidative stress and excitotoxic neuronal injury induced by β-N-methylamino-l-alanine (BMAA), a neurotoxin associated with amyotrophic lateral sclerosis/Parkinson-dementia complex in Guam, has been linked to system x c − , with BMAA acting as a transportable inhibitor simultaneously blocking cystine uptake while facilitating glutamate release (152)
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However, hyperuricemia plays a role in promoting inflammation, oxidative stress, and endothelial dysfunction underscores its potential contribution to disease pathogenesis
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