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In addition, the reaction of H 2 S with reversibly oxidised protein thiols to form a PrSS − , followed by reduction back to a PrSH by the Trx/GSH/Grx systems, prevents irreversible loss of thiols through oxidation to a sulfinic or sulfonic acid 21,22

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In addition, the intervention of a newly synthesized caffeic acid phenethyl ester (CAPE) derivative, FA-97, has alleviated DSS-induced colitis by reducing oxidative stress and inflammation, enhancing antioxidant capacity, and activating the Nrf2/HO-1 pathway, as documented (57)