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10.4269/ajtmh.20-0473 Am J Trop Med Hyg

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Future optimization strategies include the development of brain-targeted prodrugs (e.g., ester modifications, peptide conjugation), the design of nanodelivery systems (PLGA, liposomes, exosome encapsulation) to enhance brain accumulation, and the identification of next-generation RTA molecules (such as SRS11–92 and SRS16-86) with improved blood–brain barrier permeability and metabolic stability

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