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2,309 For example, one study that followed-up on 3,302 middle-aged women from across the United States for about 20 years found that, in more than 30% of participants, E2 levels were elevated during perimenopause and did not decline until less than one year before their final period

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Abbreviations: ALP (alkaline phosphatase), ALT (alanine aminotransferase), AST (aspartate aminotransferase), Bax (Bcl-2 Associated X protein), Bcl-2 (B-cell lymphoma 2), CAT (catalase), CRP (C-reactive protein), G-CSF (Granulocyte-Colony Stimulating Factor), GPx (glutathione peroxidase), GSH (reduced glutathione), IL-1β (interleukin-1 beta), iNOS (inducible nitric oxide synthase), MDA (malondialdehyde), NF-κB (nuclear factor kappa B), NO (nitric oxide), Nrf2 (Nuclear factor erythroid 2-related factor 2), SOD (superoxide dismutase), TNF-α (tumor necrosis factor-alpha), ↑ (increase), ↓ (decrease)