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On the basis of the expanding volume of currently emerging research, we have summarized several relevant targets and signaling pathways of UC, including the PI3K/AKT, NF-κB, and Wnt/β-catenin pathways, as well as the contributions of lncRNAs and miRNAs, endoplasmic reticulum stress, mitochondrial dysfunction, mesenchymal stem cells, macrophage polarization, the gut microbiota, and many other targets and pathways (Table 2)