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Lactate promotes lactic acidification of histone H4 lysine 12 (H4K12la) by downregulating histone lysine delactase, inducing the enrichment of H4K12la in the SASP promoter region and SASP transcriptional activation to promote VSMC senescence
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Glutathione works by reducing melanin production, and when you stop taking it, melanin production will slowly return to its original levels
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