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Abbreviations ALT Alanine aminotransferase AST Aspartate aminotransferase BMI Body mass index CAP Controlled attenuation parameter FBS Fasting blood sugar HbA1c hemoglobin A1c HDL High-density lipoprotein IRI Immunoreactive insulin LDL Low-density lipoprotein LSM Liver stiffness measurement NAFLD Nonalcoholic fatty liver disease NASH Nonalcoholic steatohepatitis NEFA Non-esterified fatty acid UMIN University Hospital Medical Information Network VCTE Vibration-controlled transient elastography Authors’ contributions Designed and coordinated the study: TK, YH, YS, and AN

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A melanocortin peptide, PT 141, activates melanocortin receptors in the brain