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GPX5 is described in the epididymis as a secreted protein that contains cysteine (Cys) in the active center instead of Sec, GPX5 is the first discovered Cys-based superfamily member, also known as epididymal GPX (EGPX), which has now been shown to play a role in protecting mouse sperm from hydrogen peroxide toxicity (Zhang et al., 2008
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