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Potency:50 mg
Although it is still unclear how necrosis can decrease overall survival in both pre-clinical and clinical GBMs, we suspect that secretion of pro-tumorigenic factors and/or recruitment and activation of other immune cells (e.g., microglia) by ferroptosed tumor cells may lead to certain non-autonomous tumor effects that precipitate neuroinflammation (or, more precisely, “necroinflammation”) and cerebral cytokine storm, eventually leading to irreversible cerebral edema, cachexia, multi-organ dysfunction, and death, as observed in our GBM mouse model
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