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Mechanistically, MASLD provides increased ferroptotic susceptibility through dysmetabolic iron overload syndrome, ACSL4–LPCAT3–mediated PUFA introduction, deficient SCD1/NRF2–GPX4 antioxidant defense, and sustained inflammatory signalization
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For the hyperinsulinemic–euglycemic clamp, insulin was infused at a constant rate of 4 mU/kg/min for 10 minutes and then decreased to 2 mU/kg/min
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