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5 In patients with metastatic PDAC (mPDAC) and Eastern Cooperative Oncology Group Performance Status (ECOG PS) scores of 0-1, NCCN Category 1 Preferred first-line (1L) treatment options within NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ® ) include fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX [FFX]), liposomal irinotecan, oxaliplatin, leucovorin, and fluorouracil (NALIRIFOX), and gemcitabine with nab-paclitaxel (GnP)
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The EFSA concluded that there wasn’t enough data to directly create recommendations for children, and so they used an extrapolation from the adult recommendations based on body size and applied a factor for increased needs due to growth (EFSA, 2015, p
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