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however, VEGFR-2 has been known to be activated independent of its ligand ( VEGFR-2 Considered one of the key components of endothelial proliferation and vascular growth, VEGFR-2, also known as fetal liver kinase 1 (Flk-1) or kinase insert domain receptor (KDR), is mostly found within vascular ECs, though it is also weakly expressed in other cells such as osteoblasts, hematopoietic cells, and megakaryocytes (Figure 2)

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I heard from one reader, who had the CBS mutation, and this individual ended up with selenium toxicity due to this very reason