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Aguayo et al., It is well accepted that protein kinases are able to modify GABA A R function, although the direction of this change, potentiating or depressing, depends not only on the type of kinase, but also on the neuron-type (Aguayo et al., A R γ2L subunit features a consensus sequence for PKC phosphorylation and it was reported that mutation of this region abolished PKC-dependent ethanol effects (Wafford et al., 1991