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Chronic antidepressant treatment stimulates the function of cAMP-CREB, a transcription factor that regulates the expression of genes involved in neuroplasticity, cell survival, and cognition [1], for example, cAMP-CREB, mitogen-activated protein kinase (MAPK), BFos , and serum response factor (SRF) [4]
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Therefore, it is plausible that gastrointestinal symptoms such as diarrhea seen in long Covid may be due to possible elevations of IL-1, IL-6, and TNF-Ξ± production causing post-infectious long term loss of gut integrity
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