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The authors also found that UA inhibited the activation of the NF-κB signaling pathway, which is involved in the survival of lymphoma cells [103]

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Motif enrichment analysis in KO cells showed enrichment of motifs for transcription factors involved in TGF-β signaling activation, such as JUN ( AP-1 ) and SMAD Family Member 3 ( SMAD3 ) 53 , as well as Forkhead Box P3 ( FOXP3 ), which is crucial for TGF-β-mediated regulatory T cell differentiation and immune tolerance 54