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Circulating Fe 3+ enters cells with the assistance of transferrin and subsequently converts to Fe 2+ ( 2+ can catalyze the generation of metabolically toxic reactive oxygen species and phospholipid peroxide through the Fenton reaction, leading to cell damage or death (Figure 4)

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Figure 2: Photograph of Paul Ehrlich in his laboratory (credit: Wellcome Images) with his diagram of his side chain theory which he published in its full form in a lecture he delivered to the Royal Society in London in 1900 (Ehrlich)