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First, since glutamine metabolism is the precursor to ammonia accumulation, inhibitors such as 6-diazo-5-oxo-L-norleucine (DON) or CB-839, a non-competitive allosteric inhibitor of GLS1, can significantly reduce intracellular ammonia levels (35, 124)
NuMedica
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In addition, specific biological processes and molecular functions during progressive periodontitis were revealed and a set of hub proteins, including SNCA, CA1, HBB, SLC4A1, and ANK1 was strongly associated with the clinical progression status of periodontitis
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