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Mechanistically, RBP4 may activate TLR4/JNK and TLR4/NF-κB/NLRP3 pathways, promoting inflammatory cell activation and cytokine release, which drives vascular inflammation (45, 51)
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Shear stress is detected by mechanosensors, including integrins (e.g., α5-annexin A2), CD31/PECAM-1, VE-cadherin, and VEGFR2 [46,50] , with PECAM-1 playing a pivotal role
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