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“This is really just about influencers in a huge market, and not about good science.” Caufield added that there’s a “political element” to the peptide craze

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ClinPred and other missense severity scores confirmed high sensitivity of GAT1 to amino acid substitutions (particularly within TMs 1–10, known to build the substrate binding pocket and maintain core structural architecture), which explains SLC6A1 sevenfold enrichment for pathogenic missense variants over truncating mutations in neurodevelopmental cohorts, despite the relatively small coding size of the gene (599 amino acids)