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Nicotinamide is a critical precursor for NAD + , which acts as a coenzyme in essential metabolic processes, including glycolysis, the citric acid cycle, and oxidative phosphorylation [15]
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For example, dual-gradient-responsive nanocrystals have been designed to release low doses of FXR agonists within the intestinal lumen in response to pH variations, followed by disintegration in the hypoxic hepatic microenvironment to deliver relatively high concentrations of anti-inflammatory agents
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